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Cert Medical Oncology(SA) Paed Practice Questions - CMSA Sub-specialty Certificate in Medical Oncology Cert Medical Oncology(SA) Paed - South Africa Exam

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About this Exam

Prepare with the Cert Medical Oncology(SA) Paed Practice Questions - CMSA Sub-specialty Certificate in Medical Oncology Cert Medical Oncology(SA) Paed - South Africa Exam practice quiz. This question bank includes 100 questions covering year-old, presents, mass, biopsy, and reveals. Use it to review important concepts, identify knowledge gaps, and build confidence for the related exam, course, or assessment.

Sample Questions

Question 1
A 4-year-old boy presents with pallor, lethargy, fever, and diffuse petechiae. Bone marrow aspirate confirms precursor B-cell acute lymphoblastic leukaemia (B-ALL). Cytogenetic analysis reveals a t(12;21)(p13;q22) translocation. Which gene fusion is formed by this translocation, and what is its prognostic significance?
ETV6-RUNX1 (TEL-AML1); favorable prognosis
TCF3-PBX1 (E2A-PBX1); unfavorable prognosis
KMT2A-AFF1 (MLL-AF4); favorable prognosis
BCR-ABL1; unfavorable prognosis
Question 2
A 13-year-old adolescent boy presents with a 2-week history of worsening shortness of breath, facial puffiness, orthopnoea, and venous distension over the upper chest. Chest radiograph demonstrates a massive anterior mediastinal mass with left pleural effusion. Full blood count reveals WBC 145 x 10^9/L with 85% circulating blasts. What is the most likely diagnosis?
Precursor B-cell acute lymphoblastic leukaemia (B-ALL)
Chronic myeloid leukaemia (CML)
Acute promyelocytic leukaemia (APML)
T-cell acute lymphoblastic leukaemia (T-ALL)
Question 3
Minimal residual disease (MRD) measurement at the end of induction chemotherapy is the most powerful post-treatment prognostic marker in paediatric ALL. What threshold measured by flow cytometry or quantitative PCR is standardly used to define MRD negativity?
Less than 0.0001% (< 1 in 1,000,000 cells / 10^-6)
Less than 0.01% (< 1 in 10,000 cells / 10^-4)
Less than 0.1% (< 1 in 1,000 cells / 10^-3)
Less than 1.0% (< 1 in 100 cells / 10^-2)
Question 4
A 6-month-old infant is diagnosed with acute lymphoblastic leukaemia. Immunophenotyping shows CD19+, CD22+, HLA-DR+, but CD10 (CALLA) negative blasts. Which molecular genetic alteration is found in over 70-80% of infant ALL cases and accounts for its dismal prognosis?
High hyperdiploidy (>50 chromosomes)
NUP98-NSD1 gene fusion
ETV6-RUNX1 translocation t(12;21)
KMT2A (MLL) gene rearrangement on chromosome 11q23
Question 5
An 8-year-old boy presents with rapid abdominal distension, ascites, and an ileocecal mass causing intussusception. Biopsy reveals medium-sized lymphoid cells with amphophilic cytoplasm, multiple nucleoli, a high mitotic index (>99% Ki-67 positivity), and interspersed tingible body macrophages ('starry-sky' pattern). What is the characteristic chromosomal translocation?
t(8;14)(q24;q32) translocating MYC to the IGH heavy chain locus
t(14;18)(q32;q21) translocating BCL2 to IGH
t(11;14)(q13;q32) translocating CCND1 to IGH
t(2;5)(p23;q35) translocating NPM1 to ALK

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Additional Information

Cert Medical Oncology(SA) Paed Practice Questions - CMSA Sub-specialty Certificate in Medical Oncology Cert Medical Oncology(SA) Paed - South Africa Exam

This practice set contains 100 questions from the matching question bank and focuses on year-old, presents, mass, biopsy, and reveals. Work through each question carefully, review the provided solutions, and revisit topics that need more study before your next attempt.

This is an independent study resource intended for practice and review; it is not an official examination or an endorsement by any organization named in the title.

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Frequently Asked Questions

This quiz contains a total of 100 practice questions carefully selected to test your knowledge on this subject.
Yes, you will have exactly 0 minutes to complete the exam. A countdown timer will be visible once you start.
Yes, you can retake this practice test as many times as you need. The questions and options may be randomized on subsequent attempts to ensure comprehensive learning.

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