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Cert Medical Oncology(SA) Phys Practice Questions - Sub-specialty Certificate in Medical Oncology of the College of Physicians of South Africa Exam

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About this Exam

Prepare with the Cert Medical Oncology(SA) Phys Practice Questions - Sub-specialty Certificate in Medical Oncology of the College of Physicians of South Africa Exam practice quiz. This question bank includes 100 questions covering year-old, trial, first-line, metastatic, and cancer. Use it to review important concepts, identify knowledge gaps, and build confidence for the related exam, course, or assessment.

Sample Questions

Question 1
A 48-year-old premenopausal woman undergoes a left lumpectomy and sentinel lymph node biopsy for a 2.2 cm invasive ductal carcinoma. Pathology reveals Nottingham Grade 2 tumor, ER 95%, PR 80%, HER2 1+ (negative), and 0/2 lymph nodes involved (pT2N0M0). Genomic profiling with the 21-gene Recurrence Score (Oncotype DX) yields a score of 28. Which of the following is the most appropriate systemic adjuvant therapy recommendation based on TAILORx and RxPONDER trials?
Adjuvant chemotherapy (e.g., TC - docetaxel/cyclophosphamide) followed by tamoxifen combined with ovarian function suppression
Adjuvant tamoxifen monotherapy for 5 years without chemotherapy or ovarian function suppression
Adjuvant aromatase inhibitor (letrozole) monotherapy for 5 years without chemotherapy
Adjuvant trastuzumab plus paclitaxel for 12 weeks followed by single-agent tamoxifen
Question 2
A 54-year-old woman presents with newly diagnosed metastatic HER2-positive invasive breast cancer with multiple liver and bone metastases. Echocardiogram demonstrates a left ventricular ejection fraction (LVEF) of 62%. Baseline lab tests are normal. According to the landmark CLEOPATRA trial and international guidelines, what is the preferred first-line systemic regimen?
Trastuzumab emtansine (T-DM1) monotherapy
Pertuzumab + Trastuzumab + Docetaxel
Trastuzumab + Paclitaxel + Lapatinib
Trastuzumab deruxtecan (T-DXd) + Capecitabine
Question 3
A 52-year-old female with metastatic HER2-positive breast cancer experiences disease progression in the liver and lungs while receiving first-line Pertuzumab, Trastuzumab, and Docetaxel. Her ECOG performance status is 1. What is the most appropriate second-line systemic treatment choice supported by the DESTINY-Breast03 phase III trial?
Lapatinib + Capecitabine
Trastuzumab emtansine (T-DM1)
Trastuzumab deruxtecan (T-DXd)
Tucatinib + Trastuzumab + Capecitabine
Question 4
A 42-year-old female is diagnosed with stage IIB triple-negative breast cancer (TNBC, cT2cN1M0). Core biopsy shows Nottingham Grade 3 invasive ductal carcinoma, ER <1%, PR 0%, HER2 0, PD-L1 CPS = 15. Staging scans show no distant metastases. What is the standard neoadjuvant systemic therapy strategy based on the KEYNOTE-522 trial?
Dose-dense AC (doxorubicin/cyclophosphamide) followed by paclitaxel monotherapy
Pembrolizumab monotherapy for 4 cycles followed by delayed definitive mastectomy
Carboplatin + Paclitaxel for 4 cycles followed immediately by breast-conserving surgery
Pembrolizumab + Carboplatin + Paclitaxel, followed by Pembrolizumab + AC, then post-operative adjuvant Pembrolizumab
Question 5
A 62-year-old postmenopausal female presents with de novo metastatic ER-positive, HER2-negative breast cancer involving multiple bone lesions and asymptomatic subcentimeter lung nodules. She has an ECOG performance status of 0. Which of the following represents the preferred first-line systemic management?
A CDK4/6 inhibitor (e.g., Ribociclib or Abemaciclib) combined with a non-steroidal aromatase inhibitor (Letrozole or Anastrozole)
Dose-dense AC (doxorubicin and cyclophosphamide) chemotherapy for 6 cycles
Single-agent Fulvestrant 500 mg intramuscular injection monthly
Single-agent Tamoxifen 20 mg oral daily

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Additional Information

Cert Medical Oncology(SA) Phys Practice Questions - Sub-specialty Certificate in Medical Oncology of the College of Physicians of South Africa Exam

This practice set contains 100 questions from the matching question bank and focuses on year-old, trial, first-line, metastatic, and cancer. Work through each question carefully, review the provided solutions, and revisit topics that need more study before your next attempt.

This is an independent study resource intended for practice and review; it is not an official examination or an endorsement by any organization named in the title.

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Frequently Asked Questions

This quiz contains a total of 100 practice questions carefully selected to test your knowledge on this subject.
Yes, you will have exactly 0 minutes to complete the exam. A countdown timer will be visible once you start.
Yes, you can retake this practice test as many times as you need. The questions and options may be randomized on subsequent attempts to ensure comprehensive learning.

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