CITI HUMAN SUBJECTS
RESEARCH
CERTIFICATION PRACTICE
TEST 50 QUESTIONS
Question 1: Which Belmont Report principle is most directly supported by giving a capable adult meaningful information and allowing a voluntary decision about research participation?
Choices:
1) Respect for persons 2) Bene�cence 3) Justice 4) Scienti�c validity
Correct Answer: Respect for persons
Explanation: Respect for persons recognizes autonomy and requires that capable individuals be given adequate information and a voluntary opportunity to decide whether to participate.Page 1
Question 2: A research team redesigns a blood-draw schedule so that the same
scienti�c objective can be met with fewer venipunctures. Which ethical principle is most directly re�ected?
Choices:
1) Justice 2) Bene�cence 3) Respect for persons 4) Transparency
Correct Answer: Bene�cence
Explanation: Bene�cence requires researchers to minimize possible harms and maximize possible bene�ts. Reducing unnecessary procedures lowers research risk without sacri�cing the study objective.Question 3: An investigator recruits only economically disadvantaged patients for a burdensome study mainly because they are easy to access, even though the research question does not require that population. Which Belmont principle is most clearly implicated?
Choices:
1) Respect for persons 2) Bene�cence 3) Justice 4) Fidelity
Correct Answer: Justice
Explanation: Justice concerns the fair distribution of research burdens and bene�ts. Selecting a disadvantaged group merely for convenience can impose burdens inequitably.Page 2
Question 4: Which historical development most directly created the National
Commission that later issued the Belmont Report?
Choices:
1) The National Research Act of 1974 2) The HIPAA Privacy Rule 3) The Kefauver-Harris Amendments 4) The Declaration of Helsinki alone
Correct Answer: The National Research Act of 1974
Explanation: The National Research Act of 1974 established the National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research, which later issued the Belmont Report.
Question 5: Which ethical requirement is most closely associated with the
Nuremberg Code?
Choices:
1) Mandatory payment to all subjects 2) Voluntary consent of the human subject 3) Use of placebo controls in every trial 4) Annual IRB review of all research
Correct Answer: Voluntary consent of the human subject
Explanation: The Nuremberg Code prominently established voluntary consent as a
foundational requirement for ethical research involving human participants.Page 3